TY - JOUR UR - https://doi.org/10.25259/JPATS_29_2021 DO - 10.25259/JPATS_29_2021 TI - Incidence and predictors of death among adult patients treated for tuberculosis in two regions of Cameroon: 2010 to 2015 AU - Balkissou,Adamou Dodo AU - Pefura-Yone,Eric Walter AU - Poka,Virginie AU - Kuaban,Alain AU - Mubarak,Djibril Mohammadou AU - Kora,Armel Djao AU - Raouph,Fadil Donkou AU - Lonla,Josiane Touoyem AU - Taguedjio,Linda Mangoh AU - Kuaban,Christopher AB - Objectives: Mortality during tuberculosis (TB) remains high in Africa. The purpose of our study was to determine the incidence and predictors of death during TB treatment in Cameroon. Materials and Methods: Data of subjects aged ≥15 years were retrospectively extracted from registers in all TB diagnostic and treatment centers in the Western and Northern regions of Cameroon from 2010 to 2015. Cox regression models were used to determine predictors of death during TB treatment. Results: Of the 19,681 patients included, 12,541 (63.7%) were male and their median age (25th-75th percentile) was 34 (26–45) years. The cumulative incidence (95% confidence interval [CI]) of death during TB treatment was 8.0% (7.5–8.5%). The predictors (hazard ratios [95% CI]) of death were: Age >34 years (1.479 [1.295–1.688], P < 0.001), female sex (1.471 [1.286–1.683], P < 0.001), extra-pulmonary TB (1.723 [1.466–2.026], P < 0.001), human immunodeficiency virus infection (3.739 [3.269–4.276], P < 001]), TB treatment in the Western region (2.241 [1.815–2.768], P < 0.001), treatment before 2012 (1.215 [1.073–1.376], P = 0.002)and low body weight (1st quartile and 2nd quartile) (2.568 [2.133–3.092], [P < 0.001]) and (1.569 [1.298–1.896], P < 0.001) respectively. Conclusion: The incidence of death during TB was relatively high in the Western and Northern regions of Cameroon. Recognition of these persons at greatest risk may improve care and reduce death durinng TB treatment. VL - 3 T2 - Journal of the Pan African Thoracic Society JO - Journal of the Pan African Thoracic Society J2 - Journal of the Pan African Thoracic Society SN - 2694-4561 ER -